Responsiveness of electrical nociceptive detection thresholds to capsaicin (8 %)-induced changes in nociceptive processing

Capsaicin (8%) Patch Increases Multiple Electrical Nociceptive Perception Thresholds in Healthy Human Subjects

Background: Pre-operative nociceptive thresholds are able to predict patients susceptible to developing post-operative chronic pain. Thresholds are dependent on stimulus properties (i.e. pulsewidth (PW), number of pulses (NoP), and inter-pulse interval (IPI)) and are related to different mechanisms in the nociceptive system. Measuring multiple thresholds enables a detailed observation of periph...

Dependence of Nociceptive Detection Thresholds on Physiological Parameters and Capsaicin-Induced Neuroplasticity: A Computational Study

Physiological properties of peripheral and central nociceptive subsystems can be altered over time due to medical interventions. The effective change for the whole nociceptive system can be reflected in changes of psychophysical characteristics, e.g., detection thresholds. However, it is challenging to separate contributions of distinct altered mechanisms with measurements of thresholds only. H...

Differentiating Nociceptive Mechanisms Using Electrocutaneous Detection Thresholds

Chronic pain after surgery is a frequent problem and difficult to treat. Patients at risk are not identified until early treatment is no longer effective. Persisting and chronic pain can be the result of the malfunctioning of nociceptive mechanisms; both ascending and descending pathways can, individually, attribute to chronic pain development [1]. Pain thresholds measured before and after surg...

NMDA receptor involvement in neuroplastic changes induced by neonatal capsaicin treatment in trigeminal nociceptive neurons.

NMDA receptor involvement in neuroplastic changes induced by neonatal capsaicin treatment in trigeminal nociceptive neurons. J. Neurophysiol. 78: 2799-2803, 1997. This study examines whether 1) the neonatal loss of C-fiber afferents results in neuroplastic changes in the mechanoreceptive field (RF) properties and spontaneous activity of nociceptive neurons in trigeminal subnucleus caudalis (med...

Nociceptive Neurons Induced By Neonatal Capsaicin Treatment in Trigeminal NMDA Receptor Involvement in Neuroplastic Changes